The Mechanism of Adaptation of Breast Cancer Cells to Hypoxia: Role of AMPK/mTOR Signaling Pathway

被引：7

作者：

Sorokin, D. V. ^{[1
]}

Scherbakov, A. M. ^{[1
]}

Yakushina, I. A. ^{[1
]}

Semina, S. E. ^{[1
]}

Gudkova, M. V. ^{[1
]}

Krasil'nikov, M. A. ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, NN Blokhin Russian Canc Res Ctr, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 160卷 / 04期

基金：

俄罗斯科学基金会; 俄罗斯基础研究基金会;

关键词：

breast cancer; hypoxia; AMPK; mTOR; adaptation to hypoxia; MAMMALIAN TARGET; INDUCIBLE FACTOR; TUMOR HYPOXIA; RAPAMYCIN; GROWTH; ANGIOGENESIS; SUPPRESSION; PROGRESSION; MTOR;

D O I：

10.1007/s10517-016-3217-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the mechanisms of adaptation of human breast cancer cells MCF-7 to hypoxia and analyzed the role of AMPK/mTOR signaling pathway in the maintenance of cell proliferation under hypoxic conditions. It was found that long-term culturing (30 days or more) of MCF-7 cells under hypoxic conditions induced their partial adaptation to hypoxia. Cell adaptation to hypoxia was associated with attenuation of hypoxia-dependent AMPK induction with simultaneous constitutive activation of mTOR and Akt. These findings suggest that these proteins can be promising targets for targeted therapy of tumors developing under hypoxic conditions.

引用

页码：555 / 559

页数：5

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