Association studies for finding cancer-susceptibility genetic variants

被引：395
|
作者：
Pharoah, PDP
Dunning, AM
Ponder, BAJ
Easton, DF
机构：
[1] Strangeways Res Lab, Canc Res UK Human Canc Genet Grp, Dept Oncol, Cambridge CB1 8RN, England
[2] Strangeways Res Lab, Genet Epidemiol Grp, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England
来源：
NATURE REVIEWS CANCER | 2004年 / 4卷 / 11期
关键词：
D O I：
10.1038/nrc1476
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of cancer, and it is likely that many genes with modest effects are yet to be found. Genetic-association studies have been widely used in the search for such genes, but success has been limited so far. Increased knowledge of the function of genes and the architecture of human genetic variation combined with new genotyping technologies herald a new era of gene mapping by association.
引用
收藏
页码：850 / 860
页数：11
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