Animal models for studying the etiology and treatment of low back pain

被引：44

作者：

Shi, Changgui ^{[1
]}

Qiu, Sujun ^{[2
]}

Riester, Scott M. ^{[3
]}

Das, Vaskar ^{[4
]}

Zhu, Bingqian ^{[5
]}

Wallace, Atiyayein A. ^{[4
]}

van Wijnen, Andre J. ^{[3
]}

Mwale, Fackson ^{[6
,7
]}

Iatridis, James C. ^{[8
]}

Sakai, Daisuke ^{[10
]}

Votta-Velis, Gina ^{[9
,11
]}

Yuan, Wen ^{[1
]}

Im, Hee-Jeong ^{[11
,12
]}

机构：

[1] Second Mil Med Univ China, Dept Orthoped Surg, Changzheng Hosp, Shanghai, Peoples R China

[2] Southern Med Univ, Dept Orthoped Surg, Zhujiang Hosp, Guangzhou, Guangdong, Peoples R China

[3] Mayo Clin, Dept Orthoped Surg, Rochester, MN USA

[4] Rush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA

[5] Univ Illinois, Dept Biobehav Hlth Sci, Chicago, IL USA

[6] McGill Univ, Dept Surg, Montreal, PQ, Canada

[7] SMBD Jewish Gen Hosp, Lady Davis Inst Med Res, Orthopaed Res Lab, Montreal, PQ, Canada

[8] Icahn Sch Med Mt Sinai, Leni & Peter May Dept Orthopaed, New York, NY 10029 USA

[9] Univ Illinois, Dept Anesthesiol, Chicago, IL USA

[10] Tokai Univ, Dept Orthopaed Surg, Sch Med, Hiratsuka, Kanagawa, Japan

[11] Jesse Brown Vet Affairs Med Ctr JBVAMC Chicago, Chicago, IL 60612 USA

[12] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 2018年 / 36卷 / 05期

基金：

美国国家卫生研究院;

关键词：

low back pain; animal model; discogenic pain; pain assessment; dorsal root ganglia; spinal cord; DORSAL-ROOT GANGLION; LUMBAR FACET JOINT; INTERVERTEBRAL DISC DEGENERATION; SPINAL NERVE ROOT; RAT MODEL; CHRONIC COMPRESSION; NEUROPATHIC PAIN; NUCLEUS PULPOSUS; INTRAARTICULAR INJECTION; THERMAL HYPERALGESIA;

D O I：

10.1002/jor.23741

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle-induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients. (c) 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1305-1312, 2018.

引用

页码：1305 / 1312

页数：8

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