Relative amount of telomeric sequences in terminal villi does not differ between normal term placentas and placentas from patients with well-controlled type 1 diabetes mellitus

被引：4
|
作者：
Zinkova, Alzbeta [1 ,2 ]
Marova, Dominika [3 ]
Koperdakova, Julia [3 ]
Mirchi, Tomas P. [3 ]
Korabecna, Marie [1 ,2 ]
Jirkovska, Marie [3 ]
机构：
[1] Charles Univ Prague, Fac Med 1, Dept Biol & Med Genet, Albertov 4, Prague 12800, Czech Republic
[2] Charles Univ Prague, Gen Univ Hosp, Albertov 4, Prague 12800, Czech Republic
[3] Charles Univ Prague, Fac Med 1, Dept Histol & Embryol, Albertov 4, Prague 12800, Czech Republic
来源：
PLACENTA | 2017年 / 55卷
关键词：
Diabetes; Chorionic villi; Pregnancy; qPCR; Telomere sequence; Telomere/single copy gene ratio; QUANTITATIVE PCR; GESTATIONAL-AGE; LENGTH; CAPILLARIES;
D O I：
10.1016/j.placenta.2017.04.016
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We applied qPCR to compare relative telomere length in terminal villi microdissected from term control placentas and placentas of patients suffering from type 1 diabetes. Significant differences were not found in the relative T/S ratios between placental groups or between the diabetic placentas affected and those not affected with chorangiosis. We hypothesize that there is no relationship between decreased placental proliferative ability in maternal diabetes type 1 and telomere shortening. (C) 2017 Elsevier Ltd. All rights reserved.
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页码：1 / 4
页数：4
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