Plexiform fibrohistiocytic tumor in a rare location: zygomatic arch

A case of plexiform fibrohistiocytic tumor (PFHT) developing in a 3-year-old girl who presented with the right cheek swollen was reported. Histologically, the tumor displayed multiple nodules of plexiform distribution within the deep dermis and subdermal adipose tissue, consists of mononuclear histiocyte-like cells and multinucleated osteoclast-like cells, the nodules is surrounded by spindle fibroblast-like cells. They were positive for vimentin, SMA, MSA, and CD68, but negative for AE1/AE3, desmin, S100, CD34. This case demonstrates that PFHT is a rare soft tissue neoplasm, in head and neck is more rare, various misleading morphological features should been taken into consideration in the diagnosis.