NMR Spectroscopy techniques for screening and identifying ligand binding to protein receptors

被引:861
|
作者
Meyer, B
Peters, T
机构
[1] Med Univ Lubeck, Inst Chem, D-23538 Lubeck, Germany
[2] Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany
关键词
drug design; ligand-protein interactions; NMR spectroscopy; proteins; screening;
D O I
10.1002/anie.200390233
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:864 / 890
页数:27
相关论文
共 50 条
  • [1] Application of NMR screening techniques for observing ligand binding with a protein receptor
    Shimotakahara, S
    Furihata, K
    Tashiro, M
    MAGNETIC RESONANCE IN CHEMISTRY, 2005, 43 (01) : 69 - 72
  • [2] Saturation transfer difference NMR spectroscopy for identifying ligand epitopes and binding specificities
    Meyer, B
    Klein, J
    Mayer, M
    Meinecke, R
    Möller, H
    Neffe, A
    Schuster, O
    Wülfken, J
    Ding, Y
    Knaie, O
    Labbe, J
    Palcic, MM
    Hindsgaul, O
    Wagner, B
    Ernst, B
    LEUCOCYTE TRAFFICKING: THE ROLE OF FUCOSYLTRANSFERASES AND SELECTINS, 2004, 44 : 149 - 167
  • [3] TRITIUM NMR-SPECTROSCOPY OF LIGAND-BINDING TO MALTOSE-BINDING PROTEIN
    GEHRING, K
    WILLIAMS, PG
    PELTON, JG
    MORIMOTO, H
    WEMMER, DE
    BIOCHEMISTRY, 1991, 30 (22) : 5524 - 5531
  • [4] Screening protein-ligand interactions using 1H NMR techniques for detecting the ligand
    Figueiredo, Isis Martins
    Marsaioli, Anita Jocelyne
    QUIMICA NOVA, 2007, 30 (07): : 1597 - 1605
  • [5] An NMR study of ligand binding by maltodextrin binding protein
    Gehring, K
    Zhang, XC
    Hall, J
    Nikaido, H
    Wemmer, DE
    BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1998, 76 (2-3): : 189 - 197
  • [6] Computational study of ligand binding to protein receptors
    Wembridge, Paul
    Robinson, Heather
    Novak, Igor
    BIOORGANIC CHEMISTRY, 2008, 36 (4-6) : 288 - 294
  • [7] Identifying Selectivity Filters in Protein Biosensor for Ligand Screening
    Sahil, Mohammad
    Singh, Jayanti
    Sahu, Subhankar
    Pal, Sushant Kumar
    Yadav, Ajit
    Anand, Ruchi
    Mondal, Jagannath
    JACS AU, 2023, 3 (10): : 2800 - 2812
  • [8] Estimating Protein-Ligand Binding Affinity Using High-Throughput Screening by NMR
    Shortridge, Matthew D.
    Hage, David S.
    Harbison, Gerard S.
    Powers, Robert
    JOURNAL OF COMBINATORIAL CHEMISTRY, 2008, 10 (06): : 948 - 958
  • [9] Virus-ligand interactions:: Identification and characterization of ligand binding by NMR spectroscopy
    Benie, AJ
    Moser, R
    Bäuml, E
    Blaas, D
    Peters, T
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (01) : 14 - 15
  • [10] SALMON:: Solvent accessibility, ligand binding, and mapping of ligand orientation by NMR Spectroscopy
    Ludwig, Christian
    Michiels, Paul J. A.
    Wu, Xiaoqiu
    Kavanagh, Kathryn L.
    Pilka, Ewa
    Jansson, Anna
    Oppermann, Udo
    Gunther, Ulrich L.
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (01) : 1 - 3