GGNBP2 Suppresses the Proliferation, Invasion, and Migration of Human Glioma Cells

被引：13

作者：

Zhan, Ao ^{[1
]}

Lei, Bo ^{[1
]}

Wu, Honggang ^{[1
]}

Wen, YueTao ^{[2
]}

Zheng, Liandong ^{[1
]}

Wang, Shan ^{[1
]}

Wan, Xiaoqiang ^{[1
]}

Wei, Zhenghong ^{[1
]}

机构：

[1] Peoples Hosp Leshan City, Dept Neurosurg, 238 White Tower St, Leshan 614000, Sichuan Provinc, Peoples R China

[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China

来源：

ONCOLOGY RESEARCH | 2017年 / 25卷 / 05期

关键词：

GGNBP2; Glioma; Proliferation; Invasion; Migration; MALIGNANT GLIOMAS; PROMOTE GROWTH; SELF-RENEWAL; CANCER; GLIOBLASTOMA; PATHWAY; PROGRESSION; INHIBITION; ACTIVATION;

D O I：

10.3727/096504016X14816726393937

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gliomas are the most common and aggressive type of primary adult brain tumors. Although GGNBP2 has previously been considered to be a tumor suppressor gene, little is known about the association between GGNBP2 and glioma. In this study, we clearly demonstrated that GGNBP2 was downexpressed in glioma tissues, and its downexpression is related to the pathological grade and overall survival of patients with gliomas. Overexpression of GGNBP2 suppressed the proliferation, migration, and invasion of glioma cells. Mechanistically, we demonstrated that the PI3K/Akt and Wnt/beta-catenin signaling pathways were suppressed by GGNBP2 overexpression. In contrast, knockdown of GGNBP2 has precisely the opposite effect. Collectively, these data indicate that GGNBP2 shows tumor suppressive activity in human glioma cells and may stand out as a potential therapeutic target for glioma.

引用

页码：831 / 842

页数：12

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