Associations of ATGL gene polymorphisms with chicken growth and fat traits

被引:15
|
作者
Nie, Q-H. [1 ]
Fang, M-X. [1 ,2 ]
Xie, L. [1 ]
Shen, X. [1 ]
Liu, J. [1 ]
Luo, Z-P. [1 ]
Shi, J-J. [1 ]
Zhang, X-Q. [1 ]
机构
[1] S China Agr Univ, Coll Anim Sci, Dept Anim Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China
[2] Jinan Univ, Coll Med, Dept Lab Anim Sci, Guangzhou, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
adipose triglyceride lipase; association analyses; ATGL gene; chicken; single-nucleotide polymorphism; SNP; ADIPOSE TRIGLYCERIDE LIPASE; COMPLEMENTARY DEOXYRIBONUCLEIC-ACID; HORMONE-SENSITIVE LIPASE; EXPRESSION; CLONING; LIPOLYSIS; TISSUE; PNPLA2; FAMILY; BIAS;
D O I
10.1007/BF03195726
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Adipose triglyceride lipase (ATGL) catalyses the initial step in triglyceride hydrolysis, so the ATGL gene is a candidate for growth and fat traits in chickens. Nine reported single-nucleotide polymorphisms (SNPs) located in 3 exons of the chicken ATGL gene were chosen for genotyping an F, population. Only 5 SNPs were confirmed for polymorphisms and used for association analyses. The results show that c.531G>A (p.E177Syn) was not associated with any growth and fat traits (P > 0.05), but c.782G>A (p.S261N) was associated with body weight (BW) on days 14, 21, 35, 63, 70, 77, cingulated fat width and abdominal fat pad weight (P < 0.05), and significantly associated with BW on days 42, 49, and 56 (P < 0.01). Significant associations of c.903C>T (p.F301Syn) with BW on days 49 and 77 days and crude protein content of breast muscle (P < 0.05), and c.1164G>A (p.K388Syn) with BW on day 7 (P < 0.05) were also detected. Additionally, c.1069T>C (p.L357Syn) was associated with breast muscle colour (P < 0.05), and significantly associated with crude fat (ether extract) content of breast muscle (P < 0.01). Thus the missense SNP of c.782G>A (p.S261N) was significantly associated with the largest number of chicken growth and fat traits in this study.
引用
收藏
页码:185 / 191
页数:7
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