Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation

被引：164
|
作者：
Sans, Victor [1 ]
Cronin, Leroy [2 ]
机构：
[1] Univ Nottingham, Dept Chem & Environm Engn, Nottingham NG7 2RD, England
[2] Univ Glasgow, Sch Chem, WestChem, Glasgow G12 8QQ, Lanark, Scotland
来源：
CHEMICAL SOCIETY REVIEWS | 2016年 / 45卷 / 08期
基金：
英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词：
NMR-SPECTROSCOPY; RAMAN-SPECTROSCOPY; CHEMICAL-SYNTHESIS; MASS-SPECTROMETRY; ORGANIC-SYNTHESIS; CHEMISTRY; PLATFORM; SYSTEMS; NANOPARTICLES; INTELLIGENT;
D O I：
10.1039/c5cs00793c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The employment of continuous-flow platforms for synthetic chemistry is becoming increasingly popular in research and industrial environments. Integrating analytics in-line enables obtaining a large amount of information in real-time about the reaction progress, catalytic activity and stability, etc. Furthermore, it is possible to influence the reaction progress and selectivity via manual or automated feedback optimisation, thus constituting a dial-a-molecule approach employing digital synthesis. This contribution gives an overview of the most significant contributions in the field to date.
引用
收藏
页码：2032 / 2043
页数：12
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