Circulating Ki-67 protein in plasma as a biomarker and prognostic indicator of acute lymphoblastic leukemia

被引：9

作者：

Bruey, Jean-Marie ^{[1
]}

Kantarjian, Hagop ^{[2
]}

Estrov, Zeev ^{[2
]}

Zhang, Zhong ^{[2
]}

Ma, Wanlong

Albitar, Ferras

Abdool, Adam

Thomas, Deborah ^{[2
]}

Yeh, Chenhsiung

O'Brien, Susan ^{[2
]}

Albitar, Maher

机构：

[1] Quest Diagnost Nichols Inst, Hematopathol Oncol R&D, San Juan Capistrano, CA 92675 USA

[2] Univ Texas MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USA

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 02期

关键词：

Acute lymphoblast leukemia; Circulating Ki-67; Plasma; CHRONIC LYMPHOCYTIC-LEUKEMIA; EARLY BREAST-CANCER; PROSTATE-CANCER; NUCLEAR ANTIGEN; PROLIFERATION; EXPRESSION; MARKER; LYMPHOMA; THERAPY; DISEASE;

D O I：

10.1016/j.leukres.2009.07.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tissue-based determination of Ki-67, a marker of cellular proliferation, has shown prognostic value in solid tumors and hematological malignancies. We developed and validated an electrochemiluminescence-based method for sensitive measurement of circulating Ki-67 in plasma (cKi-67). This assay demonstrated significantly higher levels of cKi-67 in patients with newly diagnosed acute lymphoblastic leukemia (ALL) (n = 27; median, 762; range, 0-4574 U/100 mu L) than in healthy control subjects (n = 114; median, 399; range, 36-2830 U/100 mu L). Moreover, elevated plasma cKi-67 was associated with significantly shorter survival in ALL patients (P = 0.05). These findings suggest that Ki-67 can be detected in circulation and has potential for use as a biomarker for predicting clinical behavior in ALL. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：173 / 176

页数：4

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