Insufficient type I IFN immunity underlies life-threatening COVID-19 pneumonia

被引：10
|
作者：
Bastard, Paul [1 ,2 ,3 ]
Zhang, Qian [3 ]
Cobat, Aurelie [1 ,2 ]
Jouanguy, Emmanuelle [1 ,2 ,3 ]
Zhang, Shen-Ying [1 ,2 ,3 ]
Abel, Laurent [1 ,2 ,3 ]
Casanova, Jean-Laurent [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, Inserm U1163, Paris, France
[2] Univ Paris, Imagine Inst, Paris, France
[3] Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
[4] Howard Hughes Med Inst, New York, NY 10065 USA
[5] Inst Imagine, Lab Genet Humaine Malad Infect, INSERM U1163, 24 Bd Montparnasse, F-75015 Paris, France
来源：
COMPTES RENDUS BIOLOGIES | 2021年 / 344卷 / 01期
关键词：
Life-threatening COVID-19; Pneumonia; Type I interferons; Inborn errors of immunity; Autoantibodies; CHRONIC MUCOCUTANEOUS CANDIDIASIS; HERPES-SIMPLEX ENCEPHALITIS; AUTOANTIBODIES; SUSCEPTIBILITY; INFECTIONS; INTERFERON; DEFICIENCY; CHILDREN; PATIENT; GAMMA;
D O I：
10.5802/crbiol.36
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We established the COVID Human Genetic Effort (www.covidhge.com) to discover the human genetic and immunological bases of the vast interindividual clinical variability between humans infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We found that about 3% of patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia were ill because of inborn errors of genes controlling type I interferon (IFN)-dependent immunity (which controls influenza virus), and at least 10% of patients with life-threatening COVID-19 pneumonia had neutralizing auto-Abs against some of the 17 individual type I IFNs. These findings indicate that impaired type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 13% of patients. These discoveries pave the way for further research into unexplained severe cases, and provide a rationale for preventing and treating the disease in individuals at risk, with recombinant type I IFNs.
引用
收藏
页码：19 / 25
页数：7
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