Structure of the human class I histocompatibility antigen, HLA-A2

被引：0
|
作者：
Bjorkman, PJ
Saper, MA
Samraoui, B
Bennett, WS
Strominger, JL
Wiley, DC [1 ]
机构：
[1] Stanford Univ, Dept Med Microbiol, Stanford, CA 94305 USA
[2] Harvard Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biol, Cambridge, MA 02138 USA
来源：
JOURNAL OF IMMUNOLOGY | 2005年 / 174卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by a-helices. A large groove between the a-helices provides a binding site for processed foreign antigens. An unknown 'antigen' is found in this site in crystals of purified HLA-A2.
引用
收藏
页码：6 / 12
页数：7
相关论文
共 50 条
  • [1] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2
    BJORKMAN, PJ
    SAPER, MA
    SAMRAOUI, B
    BENNETT, WS
    STROMINGER, JL
    WILEY, DC
    [J]. NATURE, 1987, 329 (6139) : 506 - 512
  • [2] REFINED STRUCTURE OF THE HUMAN HISTOCOMPATIBILITY ANTIGEN HLA-A2 AT 2.6A RESOLUTION
    SAPER, MA
    BJORKMAN, PJ
    WILEY, DC
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1991, 219 (02) : 277 - 319
  • [3] INTERACTION OF HUMAN HISTOCOMPATIBILITY ANTIGEN HLA-A2 WITH SYNTHETIC PEPTIDES
    BEDNAREK, MA
    PARKER, KC
    CUNNINGHAM, BR
    ZWEERINK, HJ
    COLIGAN, JE
    SPRINGER, JP
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 229 - 229
  • [4] Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2
    Gewurz, BE
    Gaudet, R
    Tortorella, D
    Wang, EW
    Ploegh, HL
    Wiley, DC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) : 6794 - 6799
  • [5] CONTRIBUTION OF CLASS-I HLA-A2 ANTIGEN IN IMMUNE-REACTIONS
    KOMLOS, L
    HART, J
    KLEIN, T
    LIVNI, E
    NOTMANN, J
    VARDIMON, D
    BENRAFAEL, Z
    HALBRECHT, I
    [J]. MEDICAL HYPOTHESES, 1995, 45 (01) : 54 - 58
  • [6] MONOCLONAL ANTIBODY TO A HUMAN HISTOCOMPATIBILITY ALLOANTIGEN, HLA-A2
    PARHAM, P
    BODMER, WF
    [J]. NATURE, 1978, 276 (5686) : 397 - 399
  • [7] CYTOTOXIC LYMPHOCYTES-T RECOGNIZE A RECONSTITUTED CLASS-I HISTOCOMPATIBILITY ANTIGEN (HLA-A2) AS AN ALLOGENEIC TARGET MOLECULE
    ELLIOTT, TJ
    EISEN, HN
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (13) : 5213 - 5217
  • [8] Epothilone B induces class I Human Leukocyte Antigen (HLA) and HLA-A2 expression in ovarian cancer cells.
    Pellicciotta, Ilenia
    Goldberg, Gary
    Shahabi, Shohreh
    [J]. CANCER RESEARCH, 2009, 69
  • [9] STRUCTURE OF CROSSREACTIVE HUMAN HISTOCOMPATIBILITY ANTIGENS HLA-A28 AND HLA-A2 - POSSIBLE IMPLICATIONS FOR THE GENERATION OF HLA POLYMORPHISM
    DECASTRO, JAL
    STROMINGER, JL
    STRONG, DM
    ORR, HT
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (12): : 3813 - 3817
  • [10] Partially modified retro-inverso pseudopeptides as non-natural ligands for the human class I histocompatibility molecule HLA-A2
    Guichard, G
    Connan, F
    Graff, R
    Ostankovitch, M
    Muller, S
    Guillet, JG
    Choppin, J
    Briand, JP
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (10) : 2030 - 2039
12345