Synthetic cinnamylphenol derivatives as cancer chemopreventive agents

被引：15
|
作者：
Ito, Chihiro
Itoigawa, Masataka
Kanematsu, Tetsufumi
Imamura, Yuuki
Tokuda, Harukuni
Nishino, Hoyoku
Furukawa, Hiroshi
机构：
[1] Tokai Gakuen Univ, Fac Human Wellness, Tempaku Ku, Nagoya, Aichi 4688514, Japan
[2] Meijo Univ, Fac Pharm, Nagoya, Aichi 4688503, Japan
[3] Kyoto Prefectural Univ Med, Dept Mol Biochem, Kamigyo Ku, Kyoto 6020841, Japan
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 07期
关键词：
cinnamylphenols; cancer chemopreventive agents; anti-tumor promoters; Epstein-Barr virus activation; two-stage mouse skin carcinogenesis;
D O I：
10.1016/j.ejmech.2006.12.024
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters). (c) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：902 / 909
页数：8
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