RETRACTED: Granisetron versus granisetron/dexamethasone combination for the treatment of nausea, retching, and vomiting after major gynecologic surgery: A randomized, double-blind study (Retracted article. See vol. 40, pg. 1048, 2018)

Background: Granisetron, a selective 5-hydroxytryptamine(3) antagonist, is effective for the treatment of patients with postoperative nausea and vomiting. Dexamethasone decreases chemotherapy-induced emesis when added to an antiemetic regimen. Objective: This study compared the efficacy of granisetron alone with granisetron/ dexa methasone combination for the treatment of nausea and vomiting after major gynecologic surgery. Methods: In this randomized, double-blind study, patients who were experiencing emetic symptoms during 0 to 3 hours after the end of anesthesia administration received granisetron 40 mug/kg IV either alone or in combination with dexamethasone 8 mg. Patients then were observed for 24 hours after study drug administration, with emetic episodes recorded and tolerability assessments performed by nursing staff blinded to treatment. Results: A total of 120 women were enrolled (n = 60 in each treatment groups mean [SD] age in the granisetron group, 44 [91 years [range, 23-63 years]; combination group, 45 [81 years [range, 21-65 years]). No significant differences in patient demographic characteristics were found between the 2 treatment groups. However, the percentage of patients free of emetic symptoms (nausea, retching, vomiting) was higher in the granisetron/dexamethasone combination group than in the granisetron group (95.0% and 80.0%, respectively; P = 0.012). No clinically serious adverse events attributed to the study drugs were observed in either group. Conclusion: In this study, the granisetron/dexamethasone combination was more effective than was granisetron alone for the management of nausea and vomiting during 0 to 3 hours after anesthesia in women undergoing major gynecologic surgery. (Clin Ther 2003;25-.507-514) Copyright (C) 2003 Excerpta Medica, Inc.