A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2,4]-triazin-7-one Derivatives as AChE Inhibitors

被引：0

作者：

Liu, Sijie ^{[1
]}

Zhang, Baohua ^{[1
]}

Jia, Pengfei ^{[1
]}

Niu, Nan ^{[1
]}

He, Jingyu ^{[1
]}

Shi, Lanxiang ^{[1
]}

机构：

[1] Shijiazhuang Univ, Coll Chem Engn, Shijiazhuang, Hebei, Peoples R China

来源：

2015 INTERNATIONAL CONFERENCE ON ENERGY, MATERIALS AND MANUFACTURING ENGINEERING (EMME 2015) | 2015年 / 25卷

关键词：

7H-thiazolo[3,2-b][1,2,4]triazin-7-ones; ionic liquid; AChE inhibitor; synthesize; ACETYLCHOLINESTERASE INHIBITORS; BIOLOGICAL EVALUATION; ALZHEIMERS-DISEASE; DESIGN;

D O I：

10.1051/matecconf/20152502002

中图分类号：

TE [石油、天然气工业]; TK [能源与动力工程];

学科分类号：

0807 ; 0820 ;

摘要：

The authors study an efficient and green approach for the synthesis of 7H-thiazolo [3, 2-b][1,2,4]triazin-7-one derivatives as AChE inhibitors. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones were designed by molecular docking, and readily prepared via a one-pot reaction in morpholine hydrosulfate ([Hnhm]HSO4) ionic liquid as the catalyst and solvent. The study of AChE inhibitory activity was carried out through using the Ellman colorimetric assay. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones had been successfully synthesized by green catalyst. Most of the target compounds exhibited more than 50% inhibition at 10 mu M.

引用

页数：6

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