Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes?

被引：41

作者：

van Geffen, Chiel ^{[1
]}

Deissler, Astrid ^{[1
,2
]}

Quante, Markus ^{[2
]}

Renz, Harald ^{[3
,4
,5
]}

Hartl, Dominik ^{[6
,7
]}

Kolahian, Saeed ^{[1
,3
,4
,5
]}

机构：

[1] Univ Hosp Tubingen, Dept Expt & Clin Pharmacol & Pharmacogen, Tubingen, Germany

[2] Univ Hosp Tubingen, Dept Gen Visceral & Transplant Surg, Tubingen, Germany

[3] Philipps Univ Marburg, Mol Diagnost, Inst Lab Med & Pathobiochem, Marburg, Germany

[4] Univ Giessen, Marburg, Germany

[5] German Ctr Lung Res DZL, Marburg Lung Ctr, Marburg, Germany

[6] Eberhard Karls Univ Tubingen, Dept Pediat 1, Tubingen, Germany

[7] Novartis Inst BioMed Res, Basel, Switzerland

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

idiopathic pulmonary fibrosis; mesenchymal stem; stromal cells; regulatory T cells; regulatory B cells; macrophages; myeloid-derived suppressor cells; pharmacotherapy; transplantation; MESENCHYMAL STEM-CELLS; SUPPRESSOR-CELLS; MYOFIBROBLAST DIFFERENTIATION; DENDRITIC CELLS; LR-MSCS; B-CELLS; STROMAL CELLS; MACROPHAGES; IMMUNOMODULATION; PIRFENIDONE;

D O I：

10.3389/fimmu.2021.663203

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune system is receiving increasing attention for interstitial lung diseases, as knowledge on its role in fibrosis development and response to therapies is expanding. Uncontrolled immune responses and unbalanced injury-inflammation-repair processes drive the initiation and progression of idiopathic pulmonary fibrosis. The regulatory immune system plays important roles in controlling pathogenic immune responses, regulating inflammation and modulating the transition of inflammation to fibrosis. This review aims to summarize and critically discuss the current knowledge on the potential role of regulatory immune cells, including mesenchymal stromal/stem cells, regulatory T cells, regulatory B cells, macrophages, dendritic cells and myeloid-derived suppressor cells in idiopathic pulmonary fibrosis. Furthermore, we review the emerging role of regulatory immune cells in anti-fibrotic therapy and lung transplantation. A comprehensive understanding of immune regulation could pave the way towards new therapeutic or preventive approaches in idiopathic pulmonary fibrosis.

引用

页数：18

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