A convenient two-step one-pot synthesis of phosphonamidates

被引:11
|
作者
Mlodnosky, KL [1 ]
Holmes, HM [1 ]
Lam, VQ [1 ]
Berkman, CE [1 ]
机构
[1] SAN FRANCISCO STATE UNIV,DEPT CHEM & BIOCHEM,SAN FRANCISCO,CA 94132
关键词
D O I
10.1016/S0040-4039(97)10421-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Phosphonamidates are formed in high yield from a one-pot sequential reaction of a phosphonyl dichloride with an alcohol and then an amine in the presence of catalytic 1H-tetrazole. Undesired disubstitution of the phoshphonyl dichloride by the alcohol or the amine is minimal due to the presence of tetrazole. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:8803 / 8806
页数:4
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