Disparate expression of the PTEN gene:: a novel finding in B-cell chronic lymphocytic leukaemia (B-CLL)

被引：37

作者：

Leupin, N

Cenni, B

Novak, U

Hügli, B

Graber, HU

Tobler, A

Fey, MF ^{[1
]}

机构：

[1] Univ Bern, Inselspital, Inst Med Oncol, Dept Clin Res, CH-3010 Bern, Switzerland

[2] Univ Bern, CH-3012 Bern, Switzerland

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 121卷 / 01期

关键词：

B-CLL; PTEN gene; microsatellite markers; allelic imbalance; loss of heterozygosity; tumour suppressor gene;

D O I：

10.1046/j.1365-2141.2003.04227.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One fifth of B-cell chronic lymphocytic leukaemia (B-CLL) patients exhibit loss of heterozygosity (LOH) at 10q23.3, the site of the tumour suppressor PTEN. Microsatellite markers mapped complete LOH to 10q23.3 in 2/41 B-CLL (5%) and allelic imbalances in 6/41 (15%). No PTEN gene mutations were found. PTEN protein expression was not detected in 11 B-CLL (28%), and was reduced in eight patients (20%). LOH or allelic imbalances at 10q23.3 were fairly frequent in B-CLL, but did not encompass the PTEN gene. Nevertheless, PTEN protein may be absent in B-CLL with a normal PTEN genotype, suggesting a role of this phosphatase in the molecular pathology of B-CLL.

引用

页码：97 / 100

页数：4

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