Enantiocontrolled synthesis of highly functionalized tropanes via [5+2] cycloaddition to η3-pyridinylmolybdenum π-complexes

被引：40
|
作者：
Malinakova, HC [1 ]
Liebeskind, LS [1 ]
机构：
[1] Emory Univ, Sanford S Atwood Chem Ctr, Atlanta, GA 30322 USA
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 24期
关键词：
D O I：
10.1021/ol000288x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A chiral, nonracemic eta (3)-pyridinyl scaffold participates in [5 + 2] cycloaddition with electron-deficient alkenes, an allene, and an alkyne to give eta (3)-allylmolybdenum bicyclic adducts, The adducts can be demetalated, providing a convergent route to highly functionalized tropanes. High enantiocontrol can be achieved throughout the cycloaddition and demetalation sequence.
引用
收藏
页码：3909 / 3911
页数：3
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