Relationship between apoptosis and proliferation in secondary tumors of the brain

被引：9
|
作者：
Vaquero, J
Zurita, M
Aguayo, C
Coca, S
机构：
[1] Autonomous Univ, Hosp Puerta Hierro, Neurosurg Serv, Madrid 28035, Spain
[2] Air Forces Madrid, Dept Pathol, Madrid, Spain
来源：
NEUROPATHOLOGY | 2004年 / 24卷 / 04期
关键词：
apoptosis; brain metastases; F7-26; marker; Ki-67; proliferative index;
D O I：
10.1111/j.1440-1789.2004.00569.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A correlation between apoptosis and proliferation in astrocytomas and oligodendrogliomas, but not in glioblastomas, has been previously reported. An index for apoptosis and proliferation was established for each tumor in a series of 20 brain metastases, and its correlation was studied using the Spearman rank correlation test. Apoptosis index (AI) ranged between 1 and 78% (mean +/- SD: 11.48 +/- 16.4). Proliferation index (PI) ranged between 2.4 and 21% (mean +/- SD: 8.23 +/- 4.8). When the relationship between AI and PI was studied, a clear correlation was found (r: 0.8965, 95% CI: 0.74-0.95; P < 0.0001). Therefore, it is concluded that a clear correlation exists between proliferation and apoptosis in secondary tumors of the brain.
引用
收藏
页码：302 / 305
页数：4
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