Fine mapping quantitative trait loci affecting milk production traits on bovine chromosome 6 in a Chinese Holstein population

被引：7
|
作者：
Mei, Gui [1 ]
Yin, Cengceng [1 ]
Ding, Xiangdong [1 ]
Zhang, Qin [1 ]
机构：
[1] China Agr Univ, Coll Anim Sci & Technol, Minist Agr, Key Lab Anim Genet & Breeding,State Key Lab Agrob, Beijing 100193, Peoples R China
来源：
JOURNAL OF GENETICS AND GENOMICS | 2009年 / 36卷 / 11期
关键词：
fine mapping; QTL; Bos Taurus autosome 6; milk production traits; BREAST-CANCER CELLS; LINKAGE DISEQUILIBRIUM; DAIRY-CATTLE; DAUGHTER DESIGN; GENE; QTL; REGION; BTA6; MAP; IDENTIFICATION;
D O I：
10.1016/S1673-8527(08)60157-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To fine map the previously detected quantitative trait loci (QTLs) affecting milk production traits on bovine chromosome 6 (BTA6), 15 microsatellite markers situated within an interval of 14.3 cM spanning from BMS690 to BM4528 were selected and 918 daughters of 8 sires were genotyped. Two mapping approaches, haplotype sharing based LD mapping and single marker regression mapping, were used to analyze the data. Both approaches revealed a quantitative trait locus (QTL) with significant effects on milk yield, fat yield and protein yield located in the segment flanked by markers BMS483 and MNB209, which spans a genetic distance of 0.6 cM and a physical distance of 1.5 Mb. In addition, the single marker regression mapping also revealed a QTL affecting fat percentage and protein percentage at marker DIK2291. Our fine mapping work will facilitate the cloning of candidate genes underlying the QTLs for milk production traits.
引用
收藏
页码：653 / 660
页数：8
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