Solid phase synthesis of [18F]labelled peptides for positron emission tomography

被引：31
|
作者：
Sutcliffe-Goulden, JL
O'Doherty, MJ
Bansal, SS
机构：
[1] Univ London Kings Coll, Dept Pharm, London SE1 8WA, England
[2] Guys Kings & St Thomas Hosp, Clin PET Ctr, London SE1 7EH, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 14期
关键词：
D O I：
10.1016/S0960-894X(00)00179-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A strategy for the solid phase synthesis of [F-18]labelled peptides has been developed. The peptides were prepared on solid support and acylated with 4-[F-18]fluorobenzoic acid using HATU within 3 min and the labelled peptide was released from the solid support within 7 min. The [F-18]labelled peptides were produced in good purity with a specific activity of 20-25 GBq/mu mol. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1501 / 1503
页数：3
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