Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides

被引：30
|
作者：
Scarel, Marco [1 ]
Marchesan, Silvia [1 ,2 ]
机构：
[1] Univ Trieste, Chem & Pharmaceut Sci Dept, Via Giorgieri 1, I-34127 Trieste, Italy
[2] Univ Trieste, Natl Interuniv Consortium Mat Sci & Technol INSTM, I-34127 Trieste, Italy
来源：
MOLECULES | 2021年 / 26卷 / 11期
关键词：
cyclopeptides; diketopiperazines; gels; hydrogels; peptides; amino acids; self-assembly; supramolecular; nanomaterials; microwave; STRUCTURAL DIVERSITY; SUPRAMOLECULAR HYDROGEL; BIOLOGICAL-ACTIVITIES; GELATION CAPABILITY; NATURAL-PRODUCTS; 2,5-DIKETOPIPERAZINES; DERIVATIVES; PEPTIDES; DESIGN; CYCLIZATION;
D O I：
10.3390/molecules26113376
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interest in a variety of fields spanning from functional materials to drug discovery. This concise review will analyze the latest advancements in their synthesis, self-assembly into gels, and their more innovative applications.
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页数：17
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