Notch, a unifying target in T-cell acute lymphoblastic leukemia?

被引：33
|
作者：
Screpanti, I
Bellavia, D
Campese, AF
Frati, L
Gulino, A
机构：
[1] Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
[2] Univ Roma La Sapienza, Ist Pasteur Fdn Cenci Bolognetti Fdn, I-00161 Rome, Italy
[3] Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy
[4] Neuromed Inst, I-86077 Pozzilli, Italy
来源：
TRENDS IN MOLECULAR MEDICINE | 2003年 / 9卷 / 01期
关键词：
D O I：
10.1016/S1471-4914(02)00003-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemogenesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor kappaB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease.
引用
收藏
页码：30 / 35
页数：6
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