Total synthesis of the anti methicillin-resistant Staphylococcus aureus peptide antibiotics TAN-1057A-D

被引：68
|
作者：
Yuan, CG [1 ]
Williams, RM [1 ]
机构：
[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 119卷 / 49期
关键词：
D O I：
10.1021/ja972670j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
TAN-1057A-D, dipeptides isolated from bacteria Flexibacter sp. PK-74 and PK-176, are new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus. We describe, in detail, the total synthesis of TAN-l057A-D by a convergent route featuring a new method to construct the cyclic amidinourea functional group.
引用
收藏
页码：11777 / 11784
页数：8
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