Involvement of nitric oxide in gastric protection of epinephrine in endotoxin intoxication in rats

被引：8
|
作者：
Hsu, DZ
Liu, MY
机构：
[1] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 70428, Taiwan
[2] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 70428, Taiwan
来源：
TOXICOLOGY | 2004年 / 204卷 / 2-3期
关键词：
lipopolysaccharide; epinephrine; gastric mucosa; nitric oxide;
D O I：
10.1016/j.tox.2004.06.059
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Reduction in blood pressure may cause gastric mucosal hypoxia and injury during endotoxin intoxication. Epinephrine is found to increase gastric mucosal perfusion while managing hypotension. Nitric oxide plays an important role in regulating gastric mucosal perfusion and maintaining gastric integrity. The aim of this study was to investigate the involvement of nitric oxide in the gastric protection of epinephrine by determining gastric mucosal lipid peroxidation, ulceration, and hemorrhage levels in endotoxin intoxication in rats. Epinephrine significantly increased gastric mucosal nitrite levels, decreased gastric mucosal lipid peroxidation levels, and ameliorated gastric ulceration and hemorrhage in endotoxin-treated rats. Furthermore, nitric oxide synthase inhibitors potently reversed the effects of epinephrine on gastric mucosa in endotoxin-treated rats. It was suggested that nitric oxide might be involved in the protective effect of epinephrine on gastric mucosal injury in endotoxin intoxication in rats. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：203 / 208
页数：6
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