Synthesis of Carbazolequinones by Formal [3+2] Cycloaddition of Arynes and 2-Aminoquinones

被引：38
|
作者：
Guo, Jian
Kiran, I. N. Chaithanya
Reddy, R. Santhosh
Gao, Jiangsheng
Tang, Meiqiong
Liu, Yuyin
He, Yun [1 ]
机构：
[1] Chongqing Univ, Sch Pharmaceut Sci, 55 Daxuecheng South Rd, Chongqing 401331, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 10期
基金：
中国国家自然科学基金;
关键词：
CALOTHRIXIN B; ARYLATION;
D O I：
10.1021/acs.orglett.6b01090
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A formal cycloaddition reaction for the synthesis of biologically and pharmaceutically important carbazolequinones via the annulation of aminoquinones with arynes has been developed. This practical and metal-free cascade reaction proceeds through successive C-C/C-N bond formations. Moreover, this novel method has been utilized for the concise synthesis of bioactive murrayaquinone A and koeniginequinone B and their analogues.
引用
收藏
页码：2499 / 2502
页数：4
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