The Involvement of Insulin Receptor Genotypes in Pre- and Co-Obese Acanthosis Nigricans Children and Adolescent

被引：0

作者：

Wang, C. H. ^{[1
,3
]}

Lin, W. D. ^{[2
]}

Bau, D. T. ^{[3
]}

Chou, I. C. ^{[1
]}

Tsai, C. H. ^{[1
]}

Tsai, F. J. ^{[1
,2
,4
]}

机构：

[1] Asia Univ, Dept Pediat, Taichung, Taiwan

[2] Asia Univ, Dept Med Res, Taichung, Taiwan

[3] Asia Univ, Terry Fox Canc Res Lab, China Med Univ Hosp, Taichung, Taiwan

[4] Asia Univ, Coll Hlth Sci, Taichung, Taiwan

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2010年 / 23卷 / 07期

关键词：

acanthosis nigricans; obesity; insulin; insulin receptor; single nucleotide polymorphism; SINGLE NUCLEOTIDE POLYMORPHISM; HOMEOSTATIC MODEL ASSESSMENT; ORAL-CANCER SUSCEPTIBILITY; BETA(3)-ADRENERGIC RECEPTOR; XRCC4; GENE; SIGNIFICANT ASSOCIATION; METABOLIC SYNDROME; RESISTANCE; MUTATION; OVERWEIGHT;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acanthosis nigricans (AN) is most commonly related to obesity as a manifestation of cutaneous insulin resistance in children and adolescents, while the interaction and time course between AN and obesity and detailed mechanism for the pre- and co-obese appearance of AN (PCOAN) in child are unclear. In this study, the involvement of insulin receptor in child PCOAN was investigated via studying the association of polymorphisms of INSR gene with PCOAN. In total, 99 children with PCOAN and 100 healthy controls recruited were genotyped and analyzed by PCR-RFLP method. Significantly different distributions were found in the frequency of the INSR His1085His genotypes, but not in other INSR genotypes, between the two groups. Our results provide not only the evidence that the T allele of INSR His1085His is correlated with the appearance of PCOAN but revealed that the insulin receptor pathway may play an important role in this PCOAN.

引用

页码：653 / 660

页数：8

共 19 条

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