Point-of-care diagnostic tests for tuberculosis disease

被引：32
|
作者：
Hong, Jia Mei [1 ]
Lee, Hyeyoung [1 ]
Menon, Nishanth, V [2 ]
Lim, Chwee Teck [2 ,3 ,4 ]
Lee, Luke P. [5 ,6 ,7 ,8 ,9 ,10 ]
Ong, Catherine W. M. [1 ,3 ,11 ]
机构：
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Infect Dis Translat Res Programme, Singapore 117599, Singapore
[2] Natl Univ Singapore, Dept Biomed Engn, Singapore 117583, Singapore
[3] Natl Univ Singapore, Inst Hlth Innovat & Technol iHealthtech, Singapore 117599, Singapore
[4] Natl Univ Singapore, Mechanobiol Inst, Singapore 117411, Singapore
[5] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
[6] Univ Calif Berkeley, Berkeley Sensor & Actuator Ctr, Berkeley, CA 94720 USA
[7] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA
[8] Univ Calif Berkeley, Biophys Grad Program, Berkeley, CA 94720 USA
[9] Harvard Univ, Harvard Med Sch, Brigham & Womens Hosp, Harvard Inst Med, Boston, MA 02115 USA
[10] Sungkyunkwan Univ, Inst Quantum Biophys, Dept Biophys, Suwon, South Korea
[11] Natl Univ Hlth Syst, 1E Kent Ridge Rd,Tower Block,10th Floor, Singapore 119228, Singapore
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2022年 / 14卷 / 639期
基金：
英国医学研究理事会;
关键词：
ACTIVE PULMONARY TUBERCULOSIS; XPERT MTB/RIF ULTRA; MYCOBACTERIUM-TUBERCULOSIS; MICROFLUIDIC PLATFORM; SMEAR MICROSCOPY; HIV; ACCURACY; CULTURE; ASSAY; TIME;
D O I：
10.1126/scitranslmed.abj4124
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Rapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs) facilitate early detection, immediate treatment, and reduced transmission of TB disease. This Review evaluates current diagnostic assays endorsed by the World Health Organization and identifies the gaps between existing conventional tests and the ideal POCT. We discuss the commercial development of new rapid tests and research studies on nonsputum-based diagnostic biomarkers from both pathogen and host. Last, we highlight advances in integrated microfluidics technology that may aid the development of new POCTs.
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页数：16
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