Visible-light induced metal-free cascade Wittig/hydroalkylation reactions

被引：17
|
作者：
Miao, Pannan [1 ]
Li, Ruining [1 ]
Lin, Xianfeng [1 ]
Rao, Liangming [2 ,3 ]
Sun, Zhankui [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Pharm, Pharma X Ctr, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
[2] Chinese Acad Sci, Huzhou Res & Ind Ctr Technol, 1366 Hongfeng Rd, Huzhou 313000, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Nutr & Hlth, 320 Yueyang Rd, Shanghai 200031, Peoples R China
来源：
GREEN CHEMISTRY | 2021年 / 23卷 / 04期
关键词：
WITTIG;
D O I：
10.1039/d1gc00091h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cascade reactions are green and powerful transformations for building multiple carbon-carbon bonds in one step. Through a relay olefination and radical addition process, we were able to develop the cascade Wittig/hydroalkylation reactions induced by visible light. This metal-free radical approach features mild conditions, robustness, and excellent functionality compatibility. It allows access to saturated C3 homologation products directly from aldehydes or ketones. The synthetic utility of this method is demonstrated by a two-step synthesis of indolizidine 209D.
引用
收藏
页码：1638 / 1641
页数：4
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