Valdecoxib, a non-steroidal anti-inflammatory drug

被引：6
|
作者：
Sony, SMM
Charles, P
Ponnuswamy, MN
Yathirajan, HS
机构：
[1] Univ Madras, Dept Crystallog & Biophys, Madras 600025, Tamil Nadu, India
[2] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2005年 / 61卷
关键词：
D O I：
10.1107/S1600536804032118
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
Valdecoxib [systematic name: 4-(5-methyl-3-phenylisoxazol-4-yl) benzenesulfonamide], C16H14N2O3S, a diaryl-substituted isoxazole, is a non-steroidal anti-inflammatory drug (NSAID) that is used for the treatment of rheumatoid arthritis, osteoarthritis and dysmenorrhea pain. The planar isoxazole ring is oriented at angles of 22.2 (1) and 54.3 (1)degrees with respect to the phenyl and benzenesulfonamide groups, respectively. N-H...O and C-H...O hydrogen bonds and N-H...pi, C-H...pi and pi-pi interactions stabilize the crystal packing.
引用
收藏
页码：O108 / O110
页数：3
相关论文
共 50 条
  • [1] The anti-inflammatory non-steroidal
    Faure, Sebastien
    [J]. ACTUALITES PHARMACEUTIQUES, 2009, 48 (489): : 53 - 58
  • [2] Non-steroidal anti-inflammatory drug hypersensitivity in children
    Alves, C.
    Romeira, A. M.
    Abreu, C.
    Carreiro-Martins, P.
    Gomes, E.
    Leiria-Pinto, P.
    [J]. ALLERGOLOGIA ET IMMUNOPATHOLOGIA, 2017, 45 (01) : 40 - 47
  • [3] Non-steroidal anti-inflammatory drug hypersensitivity in children
    Yilmaz, Ozlem
    Karagol, Hacer Ilbilge Ertoy
    Bakirtas, Arzu
    [J]. ASTIM ALLERJI IMMUNOLOJI, 2014, 12 (03): : 123 - 129
  • [4] Non-steroidal anti-inflammatory drug use in the elderly
    Pilotto, Alberto
    Sancarlo, Daniele
    Addante, Filomena
    Scarcelli, Carlo
    Franceschi, Marilisa
    [J]. SURGICAL ONCOLOGY-OXFORD, 2010, 19 (03): : 167 - 172
  • [5] HOW TO CHOOSE A NON-STEROIDAL ANTI-INFLAMMATORY DRUG
    HUSKISSON, EC
    [J]. CLINICS IN RHEUMATIC DISEASES, 1984, 10 (02): : 313 - 323
  • [6] Theophylline: A non-steroidal anti-inflammatory drug - Introduction
    Pauwels, RA
    Makino, S
    [J]. CLINICAL AND EXPERIMENTAL ALLERGY, 1998, 28 : II - II
  • [7] Non-steroidal anti-inflammatory drug promotes remyelination
    Preisner, A.
    Albrecht, S.
    Cui, Q.
    Hucke, S.
    Hartmann, C.
    Taketo, M.
    Antel, J.
    Klotz, L.
    Kuhlmann, T.
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2014, 20 : 385 - 385
  • [8] Pathogenesis of non-steroidal anti-inflammatory drug gastropathy
    Fiorucci, S
    Antonelli, E
    Morelli, O
    Morelli, A
    [J]. ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1999, 31 : S6 - S13
  • [9] A non-steroidal anti-inflammatory drug to treat eumycetoma
    Dupont, Bertrand
    [J]. LANCET INFECTIOUS DISEASES, 2016, 16 (07): : 779 - 779
  • [10] NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
    BISCARINI, L
    DELFAVERO, A
    [J]. MEDICINA-RIVISTA DELLA ENCICLOPEDIA MEDICA ITALIANA, 1989, 9 (03): : 249 - 264
12345