Ca2+ channel inhibition by endomorphins via the cloned μ-opioid receptor expressed in NG108-15 cells

被引：0
|
作者：
Mima, H [1 ]
Morikawa, H [1 ]
Fukuda, K [1 ]
Kato, S [1 ]
Shoda, T [1 ]
Mori, K [1 ]
机构：
[1] Kyoto Univ Hosp, Dept Anesthesia, Kyoto 60601, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 340卷 / 2-3期
关键词：
endomorphin; mu-opioid receptor; Ca2+ channel;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Endomorphin-1 and -2, recently isolated endogenous peptides specific for the mu-opioid receptor, inhibited Ca2+ channel currents with EC50 of 6 and 9 nM, respectively, in NG108-15 cells transformed to express the cloned rat mu-opioid receptor. On the other hand, they elicited no response in nontransfected NG108-15 cells. It is concluded that endomorphin-1 and -2 induce Ca2+ channel inhibition by selectively activating the mu-opioid receptor. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：R1 / R2
页数：2
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