Enzymatic synthesis of β-lactam antibiotics and N-fatty-acylated amino compounds by the acyl-transfer reaction catalyzed by penicillin V acylase from Streptomyces mobaraensis

被引：16

作者：

Koreishi, Mayuko ^{[1
]}

Tani, Kazuha ^{[1
]}

Ise, Yuuichi ^{[1
]}

Imanaka, Hiroyuki ^{[1
]}

Imamura, Koreyoshi ^{[1
]}

Nakanishi, Kazuhiro ^{[1
]}

机构：

[1] Okayama Univ, Fac Engn, Dept Biosci & Biotechnol, Okayama 7008530, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2007年 / 71卷 / 06期

关键词：

penicillin V acylase; Streptomyces mobaraensis; acyl transfer reaction; beta-lactam antibiotics; N-fatty-acylated amino compounds;

D O I：

10.1271/bbb.70052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Penicillin V acylase from Streptomyces mobaraensis (Sm-PVA) showed high acyl-transfer activity in reactions using methyl esters of carboxylic acid (acyl donor) and amino compounds (nucleophile), to produce the corresponding amides. Moreover, Sm-PVA had broad substrate specificity, as indicated by the fact that it catalyzed the efficient synthesis of fl-lactam antibiotics, capsaicin derivatives, and N-fatty-acyl-amino acid/N-fatty-acyl-peptide derivatives.

引用

页码：1582 / 1586

页数：5

共 5 条

[1] Influence of mass transfer limitations on the enzymatic synthesis of β-lactam antibiotics catalyzed by penicillin G acylase immobilized on glioxil-agarose
Goncalves, L. R. B.
Ferreira, A. L. O.
Fernandez-Lafuente, R.
Guisan, J. M.
Giordano, R. C.
Giordano, R. L. C.
BIOPROCESS AND BIOSYSTEMS ENGINEERING, 2008, 31 (05) : 411 - 418
[2] Influence of mass transfer limitations on the enzymatic synthesis of β-lactam antibiotics catalyzed by penicillin G acylase immobilized on glioxil-agarose
L. R. B. Gonçalves
A. L. O. Ferreira
R. Fernandez-Lafuente
J. M. Guisan
R. C. Giordano
R. L. C. Giordano
Bioprocess and Biosystems Engineering, 2008, 31 : 411 - 418
[3] Kinetically controlled acylation of 6-APA catalyzed by penicillin acylase from Streptomyces lavendulae: effect of reaction conditions in the enzymatic synthesis of penicillin V
Hormigo, Daniel
Teresa Lopez-Conejo, Maria
Serrano-Aguirre, Lara
Garcia-Martin, Alberto
Saborido, Ana
de la Mata, Isabel
Arroyo, Miguel
BIOCATALYSIS AND BIOTRANSFORMATION, 2020, 38 (04) : 253 - 262
[4] A novel acylase from Streptomyces mobaraensis that efficiently catalyzes hydrolysis/synthesis of capsaicins as well as N-Acyl-L-amino acids and N-acyl-peptides
Koreishi, M
Zhang, DM
Imanaka, H
Imamura, K
Adachi, S
Matsuno, R
Nakanishi, K
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (01) : 72 - 78
[5] ENZYMATIC-SYNTHESIS OF ANTIBIOTICS - KINETICS OF ACYL GROUP TRANSFER ONTO 6-AMINOPENICILLANIC ACID-CATALYZED BY PENICILLIN AMIDASE FROM ESCHERICHIA-COLI
KLYOSOV, AA
MARGOLIN, AL
SHVYADAS, VK
BIOORGANICHESKAYA KHIMIYA, 1977, 3 (05): : 654 - 662

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