New Triterpenoid Saponins from the Roots of Gypsophila paniculata L.

被引：24

作者：

Yao, Shun ^{[1
]}

Ma, Li ^{[1
]}

Luo, Jian-Guang ^{[1
]}

Wang, Jun-Song ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2010年 / 93卷 / 02期

关键词：

OLDHAMIANA;

D O I：

10.1002/hlca.200900194

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The seven new triterpenoid saponins 1-7 were isolated from the roots of Gypsophila paniculata L. Their structures were established by 1D- and 2D-NMR techniques, HR-MS, and acid hydrolysis. The isolated compounds include 3,28-O-bidesmosides with or without a 4-methoxycinnamoyl group (see 1 vs. 2 and 3), and 3-O-monoglucosides 4-7. All isolated saponins 1-7 and their aglycones were evaluated for their alpha-glucosidase inhibition activity. Compound 1 showed inhibitor activity against yeast alpha-glucosidase with an IC50 value of 100.9 +/- 3.3 mu M, whereas compounds 2-7 were inactive.

引用

页码：361 / 374

页数：14

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