Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma

被引：28
|
作者：
Hirakawa, Hitoshi [1 ,2 ]
Hanai, Nobuhiro [1 ]
Ozawa, Taijiro [1 ]
Suzuki, Hidenori [1 ]
Nishikawa, Daisuke [1 ]
Matayoshi, Sen [2 ]
Suzuki, Mikio [2 ]
Hasegawa, Yasuhisa [1 ]
机构：
[1] Aichi Canc Ctr Hosp, Dept Head & Neck Surg, Nagoya, Aichi 464, Japan
[2] Univ Ryukyus, Grad Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Nishihara, Okinawa 90301, Japan
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷
关键词：
sinonasal squamous cell carcinoma; neoadjuvant chemotherapy; surgery; pathological response; prognosis; DOSE CISPLATIN INFUSION; LOCALLY ADVANCED HEAD; LONG-TERM SURVIVAL; INDUCTION CHEMOTHERAPY; NECK-CANCER; PARANASAL SINUSES; EPIDEMIOLOGY; RADIOTHERAPY; COMBINATION; EXPERIENCE;
D O I：
10.1002/hed.24217
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. The significance of neoadjuvant chemotherapy followed by definitive surgery for sinonasal squamous cell carcinoma (SCC) was investigated using surgical specimens. Methods. Surgery was performed in 58 patients, including 43 patients who had received neoadjuvant chemotherapy. The pathological response was classified as grades 0 (no effect), 1 (slight effect), 2 (moderate effect), and 3 (marked effect), and its correlation with prognosis was investigated. Results. Grade 2 or 3 response was observed in 34.9% of cases that received neoadjuvant chemotherapy. Overall survival (OS), disease-free survival (DFS), locoregional control, and freedom from distant metastasis were significantly better in the effective neoadjuvant chemotherapy group (grades 2 and 3) than in the less effective neoadjuvant chemotherapy group (grades 0 and 1) and the non-neoadjuvant chemotherapy group combined. Conclusion. Pathological response to neoadjuvant chemotherapy in sinonasal SCC was related to disease prognosis. (C) 2016 Wiley Periodicals, Inc.
引用
收藏
页码：E1305 / E1311
页数：7
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