Contemporary Approaches to In-Transit Melanoma

被引:22
|
作者
Perone, Jennifer A. [1 ]
Farrow, Nellie
Tyler, Douglas S.
Beasley, Georgia M.
机构
[1] Univ Texas Med Branch, 301 Univ Blvd, Galveston, TX 77555 USA
基金
美国国家卫生研究院;
关键词
ISOLATED LIMB INFUSION; STAGE-III; MULTIINSTITUTIONAL EXPERIENCE; REGIONAL CHEMOTHERAPY; RECURRENT MELANOMA; DEFINING RESPONSE; OPEN-LABEL; MULTICENTER; IPILIMUMAB; PERFUSION;
D O I
10.1200/JOP.18.00063
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In-transit melanoma represents a distinct disease pattern of heterogeneous superficial tumors. Many treatments have been developed specifically for this type of disease, including regional chemotherapy and a variety of directly injectable agents. Novel strategies include the intralesional delivery of oncolytic viruses and immunocytokines. The combination of intralesional or regional chemotherapy with systemic immune checkpoint inhibitors also is a promising approach. In the current review, we examine the general management of the workup of patients with in-transit disease, the range of available therapies, and recommendations for specific therapies for an individual patient.
引用
收藏
页码:292 / +
页数:10
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