[11]-Chaetoglobosins from Pseudeurotium bakeri Induce G2/M Cell Cycle Arrest and Apoptosis in Human Cancer Cells

被引:9
|
作者
Duan, Fang-Fang [1 ]
Liu, Lin [1 ]
Gao, Ying [1 ]
Peng, Xiao-Gang [1 ]
Meng, Xiang-Gao [2 ]
Ruan, Han-Li [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
[2] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China
来源
JOURNAL OF NATURAL PRODUCTS | 2021年 / 84卷 / 07期
基金
中国国家自然科学基金;
关键词
CYTOCHALASAN ALKALOIDS; CHAETOGLOBOSIN; BIOSYNTHESIS;
D O I
10.1021/acs.jnatprod.0c01335
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Twelve new [11]-chaetoglobosins, chaetopseudeurins A-L (1-12), were identified from the fermentation of the endophytic fungus Pseudeurotium bakeri P1-1-1. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, and single-crystal X-ray diffraction. Compounds 2 and 5-7 exhibited significant cytotoxicities against seven human cancer cell lines, with IC50 values ranging from 4.7 +/- 1.0 to 12.2 +/- 0.7 mu M, and induced G2/M cell cycle arrest and apoptosis in MCF-7 and A427 cells dose dependently. Western blot analysis showed that compound 2 induced apoptosis of MCF-7 cells via the Bcl-2/caspase-3/PARP pathway.
引用
收藏
页码:1904 / 1914
页数:11
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