Adrenal Mass: Insight Into Pathogenesis and a Common Link With Insulin Resistance

被引:17
|
作者
Muscogiuri, Giovanna [1 ]
De Martino, Maria Cristina [2 ]
Negri, MariaRosaria [1 ]
Pivonello, Claudia [2 ]
Simeoli, Chiara [2 ]
Orio, Francesco [3 ]
Pivonello, Rosario [2 ]
Colao, Annamaria [2 ]
机构
[1] IOS & Coleman Med Futura Med Ctr, Via Alcide De Gasperi 107-109-111, I-80011 Acerra, Italy
[2] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy
[3] Parthenope Univ Naples, Dept Sports Sci & Wellness, I-80131 Naples, Italy
关键词
SPORADIC ADRENOCORTICAL TUMORS; GROWTH-FACTOR-II; FACTOR-BINDING PROTEIN-2; ADVANCED SOLID TUMORS; IGF-II; DIABETES-MELLITUS; CUSHINGS-SYNDROME; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; GAMMA AGONISTS;
D O I
10.1210/en.2016-1804
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adrenal mass (AM) is a common incidental finding detected during radiological investigations with an estimated incidence of 4%. Subjects with AM do not show any physical signs of adrenal hormonal excess, although they are often insulin resistant. Interestingly, apparently nonfunctioning AMs are often associated with a high prevalence of insulin resistance (IR) and metabolic syndrome. However, it is unclear whether AM develops from a primary IR and compensatory hyperinsulinemia or whether IR is only secondary to the slight cortisol hypersecretion by AM. Further, the degree of IR has been directly reported to correlate to the size of AM, thus allowing one to hypothesize that compensatory hyperinsulinemia to IR could be mitogenic on the adrenal cortex acting through the activation of insulin and insulinlike growth factor 1 receptors. Thus, the aim of the present article is to review the current evidence on the link between AM and compensatory hyperinsulinemia to IR.
引用
收藏
页码:1527 / 1532
页数:6
相关论文
共 50 条
  • [1] Polycystic ovary syndrome: insight into pathogenesis and a common association with insulin resistance
    Barber, Thomas M.
    Dimitriadis, George K.
    Andreou, Avgi
    Franks, Stephen
    [J]. CLINICAL MEDICINE, 2016, 16 (03) : 262 - 266
  • [2] New insight into the pathogenesis of insulin resistance in hyperthyroidism and hypothyroidism
    Heba H. El Demellawy
    Mohamed A. El Feky
    Rania A. Shoier
    Olfat G. Shaker
    [J]. The Egyptian Journal of Internal Medicine, 2013, 25 (4) : 191 - 195
  • [3] Pathophysiological Link between Insulin Resistance and Adrenal Incidentalomas
    Higgs, Jordan A.
    Quinn, Alyssa P.
    Seely, Kevin D.
    Richards, Zeke
    Mortensen, Shad P.
    Crandall, Cody S.
    Brooks, Amanda E.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (08)
  • [4] Role of the sympathetic adrenal system in the pathogenesis of the insulin resistance syndrome
    Landsberg, L
    [J]. THE METABOLIC SYNDROME X: CONVERGENCE OF INSULIN RESISTANCE, GLUCOSE INTOLERANCE, HYPERTENSION, OBESITY, AND DYSLIPIDEMIAS-SEARCHING FOR THE UNDERLYING DEFECTS, 1999, 892 : 84 - 90
  • [5] Fat mass and Obesity Associated (FTO) gene and polycystic ovary syndrome: Insight into pathogenesis and association with insulin resistance
    Parveen, Sadaf
    Khan, Saba
    Ahsan, Haseeb
    Manger, Priyanka Thapa
    Gupta, Bhavana
    Alam, Roshan
    [J]. HUMAN NUTRITION & METABOLISM, 2022, 30
  • [6] Oxidative stress in adipose tissue as a primary link in pathogenesis of insulin resistance
    Kuzmenko D.I.
    Udintsev S.N.
    Klimentyeva T.K.
    Serebrov V.Y.
    [J]. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2016, 10 (3) : 212 - 219
  • [7] Perspective: The insulin signaling system - A common link in the pathogenesis of type 2 diabetes
    Withers, DJ
    White, M
    [J]. ENDOCRINOLOGY, 2000, 141 (06) : 1917 - 1921
  • [8] THE ROLE OF ADRENAL HYPERANDROGENISM, INSULIN RESISTANCE, AND OBESITY IN THE PATHOGENESIS OF POLYCYSTIC OVARIAN SYNDROME
    RITTMASTER, RS
    DESHWAL, N
    LEHMAN, L
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 76 (05): : 1295 - 1300
  • [9] Pathogenesis of type II diabetes:: are there common causes for insulin resistance and secretion failure?
    Häring, HU
    [J]. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 1999, 107 : S17 - S23
  • [10] Insulin resistance - a common link between type 2 diabetes and cardiovascular disease
    Lebovitz, HE
    [J]. DIABETES OBESITY & METABOLISM, 2006, 8 (03): : 237 - 249