Clinical islet transplantation: Current progress and new frontiers

被引：23
|
作者：
Marfil-Garza, Braulio A. [1 ]
Shapiro, Andrew Mark James [1 ,2 ]
Kin, Tatsuya [2 ]
机构：
[1] Univ Alberta, Dept Surg, Edmonton, AB, Canada
[2] Univ Alberta, Clin Islet Transplant Program, 210 Coll Plaza,8215-112 St, Edmonton, AB T6G 2C8, Canada
来源：
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES | 2021年 / 28卷 / 03期
关键词：
beta‐ cell; diabetes; insulin; islet; transplantation; PLURIPOTENT STEM-CELLS; TYPE-1; DIABETES-MELLITUS; PORTAL-VEIN THROMBOSIS; PANCREATIC-ISLETS; KIDNEY-TRANSPLANTATION; COST-EFFECTIVENESS; DONOR SCORE; THERAPY; OUTCOMES; STRATEGIES;
D O I：
10.1002/jhbp.891
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Islet transplantation (IT) is now a robust treatment for selected patients with type 1 diabetes suffering from recurrent hypoglycemia and impaired awareness of hypoglycemia. A global soar of clinical islet transplant programs attests to the commitment of many institutions and researchers to advance IT as a potential cure for this devastating disease. However, many challenges limiting the widespread applicability of clinical IT remain. In this review, we will touch on the milestones in the history of IT and its path to clinical success, discuss the current challenges around IT, propose some possible solutions, and elaborate on the frontiers envisioned in the future of clinical IT.
引用
收藏
页码：243 / 254
页数：12
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