Fixed-Dose Combination of Tafluprost and Timolol in the Treatment of Open-Angle Glaucoma and Ocular Hypertension: Comparison with Other Fixed-Combination Products

被引：32

作者：

Hollo, Gabor ^{[1
]}

Vuorinen, Jouni ^{[2
]}

Tuominen, Juhani ^{[3
]}

Huttunen, Teppo ^{[2
]}

Ropo, Auli ^{[4
]}

Pfeiffer, Norbert ^{[5
]}

机构：

[1] Semmelweis Univ, Dept Ophthalmol, H-1085 Budapest, Hungary

[2] Oy 4Pharma Ltd, Turku, Finland

[3] Univ Turku, Dept Math & Stat, Turku, Finland

[4] Santen Oy, Clin Res & Med Affairs, Helsinki, Finland

[5] Johannes Gutenberg Univ Mainz, Med Ctr, Dept Ophthalmol, D-55122 Mainz, Germany

来源：

ADVANCES IN THERAPY | 2014年 / 31卷 / 09期

关键词：

DuoTrav (R); Fixed-dose combination; Ganfort (R); Hyperemia; Intraocular pressure; Ophthalmology; Preservative free; Side effects; Tafluprost; Timolol; Xalacom (R); TRAVOPROST; 0.004-PERCENT/TIMOLOL; 0.5-PERCENT; LATANOPROST; 0.005-PERCENT/TIMOLOL; BIMATOPROST; 0.03-PERCENT/TIMOLOL; INTRAOCULAR-PRESSURE CONTROL; INDIVIDUAL COMPONENTS; OPHTHALMIC SOLUTION; RECEPTOR AGONIST; FREE ACID; EFFICACY; SAFETY;

D O I：

10.1007/s12325-014-0151-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A new preservative-free fixed-dose combination of 0.0015% tafluprost, a prostaglandin F-2 alpha analog, and 0.5% timolol (TAF/TIM; Santen Oy, Tampere, Finland), a beta-adrenergic antagonist has recently been developed. The intraocular pressure (IOP) reduction with TAF/TIM in open-angle glaucoma and ocular hypertension is similar to that of other prostaglandin-timolol fixed-combination products. Patients with high IOP responded well to TAF/TIM with reductions of up to 40% (> 13 mmHg) and beyond. Compared to previous controlled and double-masked clinical trials with DuoTrav(A (R)) (Alcon, Fort Worth, USA) and Ganfort(A (R)) (Allergan, Irvine, USA), TAF/TIM caused less superficial ocular side effects and less conjunctival hyperemia. Plausible explanations for the differences in side effects between the fixed-combination products are discussed.

引用

页码：932 / 944

页数：13

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