Expression of c-Fos protein in the brain after intravenous injection of ghrelin in rats

被引：32
|
作者：
Takayama, Kiyoshige
Johno, Yukimi
Hayashi, Kaori
Yakabi, Koji
Tanaka, Teruyuki
Ro, Shoki
机构：
[1] Gunma Univ, Sch Hlth Sci, Dept Lab Sci, Maebashi, Gunma 3718514, Japan
[2] Saitama Med Ctr, Dept Internal Med 1, Kawagoe, Saitama 3508550, Japan
[3] Teikyo Univ, Sch Med, Dept Internal Med 3, Ichihara, Chiba 2990111, Japan
来源：
NEUROSCIENCE LETTERS | 2007年 / 417卷 / 03期
关键词：
ghrelin; gastric acid secretion; c-Fos; neurons; central nervous system;
D O I：
10.1016/j.neulet.2007.02.089
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, we surveyed central neurons that might be activated after peripheral administration of a gut-brain peptide ghrelin, by examining neurons expressing c-Fos protein. First, we examined the relationship between the dose of ghrelin and the amount of gastric acid secreted. Ghrelin induced a significant increase in the amount of gastric acid secretion in a dose-dependent manner. Secondly, we examined central neurons that expressed c-Fos protein after intravenous injection of ghrelin. We found that intravenously injected ghrelin induced the neural expression of c-Fos protein in several nuclei and circumventricular organs in the brain. These results suggest that ghrelin released into the circulation may stimulate central neurons that have some role in the control mechanism for gastric acid secretion. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：292 / 296
页数：5
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