Donor lymphocyte infusion for treatment of life-threatening respiratory syncytial virus infection following bone marrow transplantation

被引：24
|
作者：
Kishi, Y
Kami, M
Oki, Y
Kazuyama, Y
Kawabata, M
Miyakoshi, S
Morinaga, S
Suzuki, R
Mori, S
Muto, Y
机构：
[1] Otsuka Pharmaceut Co Ltd, Dept Hematol, Tokushima, Japan
[2] Otsuka Pharmaceut Co Ltd, Dept Resp Dis, Tokushima, Japan
[3] Otsuka Pharmaceut Co Ltd, Otsuka Assay Labs, Tokushima, Japan
[4] Aichi Canc Ctr, Lab Chemotherapy, Aichi, Japan
[5] Tokyo Metropolitan Komagome Hosp, Bone Marrow Transplantat Team, Tokyo, Japan
来源：
BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 05期
关键词：
respiratory syncytial virus; donor lymphocyte infusion; steroid pulse therapy; bone marrow transplantation; interstitial pneumonia;
D O I：
10.1038/sj.bmt.1702559
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
We describe two patients who developed respiratory syncytial virus (RSV) pneumonia after BMT, One died of RSV pneumonia after three courses of steroid pulse therapy. Surprisingly, RSV antigen was identified in the bronchoalveolar lavage fluid (BALF) obtained post mortem, Steroid pulse therapy might have suppressed anti-RSV immunity, leading to persistent RSV infection for more than 1 month. The other patient received donor lymphocyte infusions (DLI) for relapsed plasma cell leukemia, while having active RSV pneumonia, His respiratory condition improved after DLI, and RSV antigen disappeared in BALF and nasal swabs, DLI might be effective in cases of life-threatening RSV pneumonia.
引用
收藏
页码：573 / 576
页数：4
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