How can nanotechnology help the fight against breast cancer?

被引:38
|
作者
Avitabile, Elisabetta [1 ]
Bedognetti, Davide [2 ]
Ciofani, Gianni [3 ,4 ]
Bianco, Alberto [5 ]
Delogu, Lucia Gemma [1 ,6 ,7 ]
机构
[1] Univ Sassari, Dept Chem & Pharm, Via Vienna 2, I-07100 Sassari, Italy
[2] Sidra Med & Res Ctr, Div Translat Med, Immunol & Therapy Sect, Doha, Qatar
[3] Ist Italiano Tecnol, Smart Biointerfaces, Viale Rinaldo Piaggio 34, I-56025 Pontedera, Italy
[4] Politecn Torino, Dept Mech & Aerosp Engn, Corso Duca Abruzzi 24, I-10129 Turin, Italy
[5] Univ Strasbourg, CNRS, UPR 3572, Immunol Immunopathol & Therapeut Chem, F-67000 Strasbourg, France
[6] Ist Ric Pediat Citta Speranza, Corso Stati Uniti 4, I-35129 Padua, Italy
[7] Univ Trieste, Dipartimento Sci Chim & Farmaceut, Via Licio Giorgeri 1, I-34127 Trieste, Italy
关键词
MAGNETIC NANOPARTICLES; PHOTOTHERMAL THERAPY; DRUG-DELIVERY; CELLS; NANOPROBES; ACID;
D O I
10.1039/c8nr02796j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this review we provide a broad overview on the use of nanotechnology for the fight against breast cancer (BC). Nowadays, detection, diagnosis, treatment, and prevention may be possible thanks to the application of nanotechnology to clinical practice. Taking into consideration the different forms of BC and the disease status, nanomaterials can be designed to meet the most forefront objectives of modern therapy and diagnosis. We have analyzed in detail three main groups of nanomaterial applications for BC treatment and diagnosis. We have identified several types of drugs successfully conjugated with nanomaterials. We have analyzed the main important imaging techniques and all nanomaterials used to help the non-invasive, early detection of the lesions. Moreover, we have examined theranostic nanomaterials as unique tools, combining imaging, detection, and therapy for BC. This state of the art review provides a useful guide depicting how nanotechnology can be used to overcome the current barriers in BC clinical practice, and how it will shape the future scenario of treatments, prevention, and diagnosis, revolutionizing the current approaches, e.g., reducing the suffering related to chemotherapy.
引用
收藏
页码:11719 / 11731
页数:13
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