ZrCl4 as an efficient catalyst for one-pot synthesis of highly functionalized piperidines via multi-component organic reactions

被引：33

作者：

Aboonajmi, Jasem ^{[1
]}

Mousavi, Mir Rasul ^{[1
]}

Maghsoodlou, Malek Taher ^{[1
]}

Hazeri, Nourallah ^{[1
]}

Masoumnia, Amin ^{[1
]}

机构：

[1] Univ Sistan & Baluchestan, Dept Chem, Fac Sci, Zahedan, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2015年 / 41卷 / 04期

关键词：

Multi-component reaction; One-pot; Zirconium(IV) chloride; Piperidine; Heterocycle; Aniline; ECONOMIC PASE SYNTHESIS; 5-COMPONENT CONDENSATION; SUBSTITUTED PIPERIDINES; FACILE ACCESS; DERIVATIVES; INHIBITORS; TETRAHYDROPYRIDINES; ATOM; ALKALOIDS; AGONISTS;

D O I：

10.1007/s11164-013-1320-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly atom-economic, one-pot synthesis of functionalized piperidines is reported by a multi-component condensation reaction between beta-keto ester, two equivalents of aromatic aldehyde, and two equivalents of amine in the presence of a catalytic amount of ZrCl4. The advantages of this protocol are good yields, short reaction time, mild reaction conditions, no need for column chromatography, more readily available, inexpensive catalyst, and simple work-up procedure.

引用

页码：1925 / 1934

页数：10

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Amin Masoumnia
[J]. Research on Chemical Intermediates, 2015, 41 : 1925 - 1934
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