Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: The Suita study

被引：36

作者：

Kosaka, Takayuki ^{[1
]}

Kokubo, Yoshihiro ^{[2
]}

Ono, Takahiro ^{[1
]}

Sekine, Shinichi ^{[3
]}

Kida, Momoyo ^{[1
]}

Kikui, Miki ^{[1
]}

Yamamoto, Masaaki ^{[1
]}

Watanabe, Makoto ^{[2
]}

Amano, Atsuo ^{[3
]}

Maeda, Yoshinobu ^{[1
]}

Miyamoto, Yoshihiro ^{[2
]}

机构：

[1] Osaka Univ, Grad Sch Dent, Dept Prosthodont Gerodontol & Oral Rehabil, Suita, Osaka 5650871, Japan

[2] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Suita, Osaka 5658565, Japan

[3] Osaka Univ, Grad Sch Dent, Dept Prevent Dent, Suita, Osaka 5650871, Japan

来源：

ATHEROSCLEROSIS | 2014年 / 237卷 / 01期

关键词：

Salivary inflammatory cytokine; Carotid atherosclerosis; Intima-media thickness; Periodontal disease; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE; PERIODONTAL-DISEASE; BLOOD-PRESSURE; RISK; ASSOCIATION; BIOMARKERS; INFECTION; EPIDEMIOLOGY; IMPACT;

D O I：

10.1016/j.atherosclerosis.2014.08.046

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Salivary biomarkers have been recently useful of periodontal disease, which is also risk factor of atherosclerosis. However, there are few studies of the association between salivary inflammatory cytokines and carotid atherosclerosis. We aimed to clarify the association between salivary inflammatory cytokines and periodontal disease and carotid atherosclerosis in a general urban population. Methods: We studied 608 Japanese men and women (mean age: 65.4 years) in the Suita study. Carotid atherosclerosis was evaluated by high-resolution ultrasonography with atherosclerotic indexes of intima-media thickness (IMT). Periodontal status was evaluated by the Community Periodontal Index (CPI). Salivary levels of interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha (TNF-alpha), and prostaglandin E2 (PGE2) were measured by enzyme linked immunosorbent assay. The risks of carotid atherosclerosis (>= 75th percentiles of mean-[0.88 mm] and Max-IMT [1.50 mm]) according to the quartiles of salivary inflammatory cytokines were compared using of adjusted-logistic regression models. Results and conclusion: All salivary inflammatory cytokines were positively associated with CPI. The adjusted odds ratios for carotid atherosclerosis of mean-IMT in the highest quartile of interleukin-6 and TNF-alpha were higher than those in the lowest quartiles (OR = 2.32 and 2.88; 95% confidence intervals = 1.19 -4.51 and 1.51-5.49, respectively). The adjusted odds ratio for carotid atherosclerosis of mean-IMT in the highest quartile of PGE2 was greater than those in the lowest quartile inwomen(OR = 2.78; 95% confidence intervals = 1.11-6.95). In conclusion, higher levels of salivary inflammatory cytokines were associated with both periodontal disease and carotid atherosclerosis. Selected salivary inflammatory cytokines may be useful screening markers for periodontal disease and carotid atherosclerosis. (C) 2014 Published by Elsevier Ireland Ltd.

引用

页码：123 / 128

页数：6

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