Synthesis and Properties of N,N′-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: IX. N-(1,7,7-Trimethylbicyclo[2.2.1]heptan-2-yl) Ureas and Thioureas

被引：2
|
作者：
Kuznetsov, Ya P. [1 ]
Degtyarenko, E. K. [1 ]
Burmistrov, V. V. [1 ]
Saeef, M. H. Abbas [1 ]
Pitushkin, D. A. [2 ]
Vernigora, A. A. [1 ]
Butov, G. M. [2 ]
机构：
[1] Volgograd State Tech Univ, Volgograd 400005, Russia
[2] Volgograd State Tech Univ, Volzhsky Polytech Inst Branch, Volzhsky 404121, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 57卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
natural compounds; bicyclo[2; 2; 1]heptane; isocyanate; isothiocyanate; urea; halogen-containing aromatic isocyanates; soluble epoxide hydrolase; optical isomerism; racemate; DERIVATIVES; INHIBITOR;
D O I：
10.1134/S1070428021040035
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N,N '-Disubstituted ureas and thioureas containing a lipophilic optically active natural bicyclic moiety have been synthesized by reactions of (R)-, (S)-, and (RS)-1,1,7-trimethylbicyclo[2.2.1]heptan-2-amines with aromatic isocyanates and isothiocyanates in up to 85% and 88% yield, respectively, with the goal of estimating enantiomeric stereospecificity of human soluble epoxide hydrolase (hsEH). The synthesized com-pounds are promising as inhibitors of RNA viruses and hsEH.
引用
收藏
页码：515 / 523
页数：9
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