An efficient stereoselective synthesis of substituted 1,3-dienes

被引：1
|
作者：
Oh, K
Parsons, PJ [1 ]
Cheshire, D
机构：
[1] Univ Sussex, Dept Chem, Brighton BN1 9QJ, E Sussex, England
[2] AstraZeneca Pharmaceut, Dept Med Chem, Loughborough LE11 5RH, Leics, England
来源：
SYNLETT | 2004年 / 15期
关键词：
aziridine; Ireland-Claisen rearrangement; Sharpless asymmetric epoxidation; silicon-mediated fragmentation;
D O I：
10.1055/s-2004-8356022
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A stereoselective synthesis of substituted 1,3-dienes has been developed which utilises an Ireland-Claisen rearrangement/silicon-mediated fragmentation sequence. This sequence has been designed to introduce remote centres of asymmetry as well as stereodefined diene systems, and its application to an aziridine system is also described.
引用
收藏
页码：2771 / 2775
页数：5
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