Flatiron mice and ferroportin disease

被引：0
|
作者：
Johnson, Erin E.
Wessling-Resnick, Marianne
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA USA
来源：
NUTRITION REVIEWS | 2007年 / 65卷 / 07期
关键词：
iron transport; ferroportin; hemochromatosis;
D O I：
10.1301/nr.2007.jul.341-345
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Flatiron mice provide the first genetic model that fully recapitulates the iron-loading disorder ferroportin disease. Unlike the other known genetic causes of hemochromatosis, missense mutations in the ferroportin gene are autosomal dominant. These new findings show that ferroportin disease results from dominant negative effects rather than haplo-insufficiency.
引用
收藏
页码：341 / 345
页数：5
相关论文
共 50 条
  • [1] Trace Element Distribution in Flatiron Mice, a Genetic Model of Human Ferroportin Disease
    Seo, Young Ah
    Wessling-Resnick, Marianne
    [J]. FASEB JOURNAL, 2016, 30
  • [2] Ferroportin deficiency impairs manganese metabolism in flatiron mice
    Seo, Young
    Wessling-Resnick, Marianne
    [J]. FASEB JOURNAL, 2014, 28 (01):
  • [3] Ferroportin deficiency impairs manganese metabolism in flatiron mice
    Seo, Young Ah
    Wessling-Resnick, Marianne
    [J]. FASEB JOURNAL, 2015, 29 (07): : 2726 - 2733
  • [4] The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease
    Zohn, Irene E.
    De Domenico, Ivana
    Pollock, Andrew
    Ward, Diane McVey
    Goodman, Jessica F.
    Liang, Xiayun
    Sanchez, Amaru J.
    Niswander, Lee
    Kaplan, Jerry
    [J]. BLOOD, 2007, 109 (10) : 4174 - 4180
  • [5] Of mice and iron: ferroportin disease
    Andrews, Nancy C.
    [J]. BLOOD, 2007, 109 (10) : 4115 - 4115
  • [6] The flatiron mutation in mouse ferroportin acts as a dominant negative to cause Hemochromatosis Type IV
    De Domenico, I.
    Zohn, I. E.
    Pollock, A.
    Ward, D. M.
    Goodman, J. F.
    Liang, X.
    Sanchez, A. J.
    Niswander, L.
    Kaplan, J.
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 2007, 82 (06) : 529 - 529
  • [7] The ferroportin disease
    Pietrangelo, A
    [J]. BLOOD CELLS MOLECULES AND DISEASES, 2004, 32 (01) : 131 - 138
  • [8] Distribution of manganese and other biometals in flatiron mice
    Seo, Young Ah
    Elkhader, Jamal A.
    Wessling-Resnick, Marianne
    [J]. BIOMETALS, 2016, 29 (01) : 147 - 155
  • [9] Distribution of manganese and other biometals in flatiron mice
    Young Ah Seo
    Jamal A. Elkhader
    Marianne Wessling-Resnick
    [J]. BioMetals, 2016, 29 : 147 - 155
  • [10] Ferroportin is a monomer in vivo in mice
    Pignatti, E
    Mascheroni, L
    Sabelli, M
    Barelli, S
    Biffo, S
    Pietrangelo, A
    [J]. BLOOD CELLS MOLECULES AND DISEASES, 2006, 36 (01) : 26 - 32
12345