FOXP2 and the neuroanatomy of speech and language

被引:287
|
作者
Vargha-Khadem, F
Gadian, DG
Copp, A
Mishkin, M
机构
[1] Univ London, Inst Child Hlth, London WC1N 1EH, England
[2] Great Ormond St Hosp Children, London WC1N 1EH, England
[3] NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA
基金
英国医学研究理事会;
关键词
D O I
10.1038/nrn1605
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
That speech and language are innate capacities of the human brain has long been widely accepted, but only recently has an entry point into the genetic basis of these remarkable faculties been found. The discovery of a mutation in FOXP2 in a family with a speech and language disorder has enabled neuroscientists to trace the neural expression of this gene during embryological development, track the effects of this gene mutation on brain structure and function, and so begin to decipher that part of our neural inheritance that culminates in articulate speech.
引用
收藏
页码:131 / 138
页数:8
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