The Epidemiology of Gastric Cancers in the Era of Helicobacter pylori Eradication: A Nationwide Cancer Registry-Based Study in Taiwan

被引:14
|
作者
Chang, Jeffrey S. [1 ]
Kuo, Sung-Hsin [2 ,3 ,4 ,5 ,6 ]
Chu, Pei-Yi [1 ,7 ,8 ]
Shan, Yan-Shen [9 ,10 ]
Tsai, Chia-Rung [1 ]
Tsai, Hui-Jen [1 ,11 ,12 ]
Chen, Li-Tzong [1 ,11 ,12 ,13 ]
机构
[1] Natl Hlth Res Inst, Natl Inst Canc Res, Tainan, Taiwan
[2] Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan
[3] Natl Taiwan Univ, Coll Med, Taipei, Taiwan
[4] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan
[5] Natl Taiwan Univ, Canc Res Ctr, Coll Med, Taipei, Taiwan
[6] Natl Taiwan Univ, Grad Inst Oncol, Coll Med, Taipei, Taiwan
[7] Show Chwan Mem Hosp, Dept Pathol, Changhua, Taiwan
[8] Fu Jen Catholic Univ, Coll Med, Sch Med, New Taipei, Taiwan
[9] Natl Cheng Kung Univ Hosp, Dept Surg, Tainan, Taiwan
[10] Natl Cheng Kung Univ, Inst Clin Med, Tainan, Taiwan
[11] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, Tainan, Taiwan
[12] Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan
[13] Natl Cheng Kung Univ, Inst Mol Med, Tainan, Taiwan
关键词
MARGINAL-ZONE LYMPHOMAS; MALT LYMPHOMA; INFECTION; RISK; MANAGEMENT; THERAPY; ADENOCARCINOMA; METAANALYSIS; POPULATION; TUMORS;
D O I
10.1158/1055-9965.EPI-19-0355
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Helicobacter pylori eradication has been shown to decrease gastric adenocarcinoma risk. The epidemiology of gastric lymphoma, which is also associated with H. pylori, and other rare subtypes of gastric cancer is less clear. This study comprehensively evaluated the incidence trend and the survival of gastric cancer in Taiwan by histologic subtype. Methods: The incidence trends of gastric cancer in Taiwan from 1996 and 2013 were evaluated using data from the Taiwan Cancer Registry. The life-table method and the Cox proportional hazards analysis were used to evaluate the survival of gastric cancer. Results: The incidence of all gastric cancers in Taiwan decreased from 15.97 per 100,000 in 1996 to 11.57 per 100,000in2013. Themost frequent histologic subtype of gastric cancer in Taiwan was adenocarcinoma, followed by lymphoma and sarcoma (mainly gastrointestinal stromal tumor). The best survival was in patients with sarcoma, followed by lymphoma, neuroendocrine tumor, and adenocarcinoma. Generally, women had a better survival than men. The incidence of adenocarcinoma significantly decreased from 13.56 per 100,000 in 1996 to 9.82 per 100,000 in 2013 (P < 0.0001). In contrast, the incidences of mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma did not decrease. Conclusions: The incidence of adenocarcinoma and lymphoma, both of which are associated with H. pylori, showed diverging trends. The survival of gastric cancer differed by histologic subtype and sex. Impact: The disparity in the incidence trends between gastric lymphoma and adenocarcinoma, both associated with H. pylori, warranted the need to search for additional risk factors of gastric lymphoma.
引用
收藏
页码:1694 / 1703
页数:10
相关论文
共 50 条
  • [1] The epidemiology of gastric cancer in the era of H. pylori eradication: a nation-wide registry-based study in Taiwan
    Tsai, Hui-Jen
    Chang, Jeffrey S.
    Shan, Yan-Shen
    Tsai, Chia-Rung
    Chen, Li-Tzong
    [J]. CANCER SCIENCE, 2018, 109 : 1437 - 1437
  • [2] Epidemiology of Helicobacter pylori and gastric cancer
    Kikuchi S.
    [J]. Gastric Cancer, 2002, 5 (1) : 6 - 15
  • [3] The Epidemiology of Neuroendocrine Tumors in Taiwan: A Nation-Wide Cancer Registry-Based Study
    Tsai, Hui-Jen
    Wu, Chun-Chieh
    Tsai, Chia-Rung
    Lin, Sheng-Fung
    Chen, Li-Tzong
    Chang, Jeffrey S.
    [J]. PLOS ONE, 2013, 8 (04):
  • [4] Eradication of Helicobacter pylori for prevention of gastric cancer
    Wong, Benjamin C. Y.
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2012, 27 : 5 - 6
  • [5] Chemoprevention of gastric cancer by Helicobacter pylori eradication?
    Hill, MJ
    [J]. PROGRESS IN GASTRIC CANCER RESEARCH 1997: PROCEEDINGS OF THE 2ND INTERNATIONAL GASTRIC CANCER CONGRESS, 1997, : 9 - 16
  • [6] Helicobacter pylori eradication for gastric cancer prevention
    Ito, Masanori
    [J]. EXPERT REVIEW OF ANTICANCER THERAPY, 2010, 10 (01) : 1 - 3
  • [7] The prevention of gastric cancer by Helicobacter pylori eradication
    Argueta, Erick A.
    Moss, Steven F.
    [J]. CURRENT OPINION IN GASTROENTEROLOGY, 2021, 37 (06) : 625 - 630
  • [8] Helicobacter pylori eradication for gastric cancer prevention
    Ting Kin Cheung
    Harry H.X. Xia
    Benjamin C.Y. Wong
    [J]. Journal of Gastroenterology, 2007, 42 : 10 - 15
  • [9] Helicobacter pylori eradication for preventing gastric cancer
    Bin Lu
    Meng Li
    [J]. World Journal of Gastroenterology, 2014, (19) : 5660 - 5665
  • [10] Prevention of Gastric Cancer by Helicobacter pylori Eradication
    Asaka, Masahiro
    Kato, Mototsugu
    Graham, David Y.
    [J]. INTERNAL MEDICINE, 2010, 49 (07) : 633 - 636